Yoán Moncada / Yasmani Grandal / José Abreu / Eloy Jiménez

As Sunday's game between White Sox and Cardinals heading into the bottom of the fifth inning, St. Louis reliever Roel Ramirez came into the game to make his MLB debut. The White Sox lineup did not make him feel very welcomed as they proceeded to hit back-to-back-to-back-to-back home runs off the 25-year-old. With two runners on, Yoan Moncada slugged a homer to right field, and then it was solo shots from Yasmani Grandal, Jose Abreu and Eloy Jimenez. This marked the second time in franchise history such a feat occurred, as it happened once more on August 14, 2008 vs. Kansas City.