Ken Griffey / Ken Griffey Jr.

Ken Griffey Jr. & Sr. had undeniable chemistry when sharing the diamond, and it should come as little surprise that this father/son duo became the first to hit back-to-back home runs in a Major League Baseball game. The home runs were belted in the first inning of a contest between the Griffey's Seattle Mariners and the California Angels, a game the Mariners would end up losing, 7-5.